G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells.
نویسندگان
چکیده
منابع مشابه
G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits.
Heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) are central to the signaling processes of multicellular organisms. We have explored the diversity of the G protein subunits in mammals and found evidence for a large family of genes that encode the alpha subunits. Amino acid sequence comparisons show that the different alpha subunits fall into at least three classes. The...
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Agonist binding is related to a series of motions in G protein-coupled receptors (GPCRs) that result in the separation of transmembrane helices III and VI at their cytosolic ends and subsequent G protein binding. A large number of smaller motions also seem to be associated with activation. Most helices in GPCRs are highly irregular and often contain kinks, with extensive literature already avai...
متن کاملFunctional interaction between TAS2R receptors and G-protein alpha subunits expressed in taste receptor cells.
Bitter taste perception is a conserved chemical sense against the ingestion of poisonous substances in mammals. It could be mediated by G protein-coupled receptors that need the appropriate G proteins to transduce the signals. TAS2R receptors and a G protein α subunit, α–gustducin are believed to be key molecules for its perception (Margolskee, 2002; Montmayeur and Matsunami, 2002), but little ...
متن کاملG-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.
Myristoylation of seven different alpha subunits of guanine nucleotide-binding regulatory proteins (G proteins) was examined by expressing these proteins in monkey kidney COS cells. Metabolic labeling studies of cells transfected with cytomegalovirus-based expression vectors indicated that [3H]myristate was incorporated into alpha i1, alpha i2, alpha i3, alpha 0, alpha t, and alpha z but not al...
متن کاملFunctional interaction between T2R taste receptors and G-protein alpha subunits expressed in taste receptor cells.
Bitter taste perception is a conserved chemical sense against the ingestion of poisonous substances in mammals. A multigene family of G-protein-coupled receptors, T2R (so-called TAS2R or TRB) receptors and a G-protein alpha subunit (Galpha), gustducin, are believed to be key molecules for its perception, but little is known about the molecular basis for its interaction. Here, we use a heterolog...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1991
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.88.13.5587